Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex.

@article{Eder2007PhospholipaseCC,
  title={Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex.},
  author={Petra Eder and Daniel Probst and Christian Rosker and Michael Poteser and Heimo Wolinski and Sepp D. Kohlwein and Christoph Romanin and Klaus Groschner},
  journal={Cardiovascular research},
  year={2007},
  volume={73 1},
  pages={111-9}
}
OBJECTIVE Members of the classical transient receptor potential protein (TRPC) family are considered as key components of phospholipase C (PLC)-dependent Ca2+ signaling. Previous results obtained in the HEK 293 expression system suggested a physical and functional coupling of TRPC3 to the cardiac-type Na+/Ca2+ exchanger, NCX1 (sodium calcium exchanger 1). This study was designed to test for expression of TRPC3 (transient receptor potential channel 3) and for the existence of a native TRPC3/NCX1… CONTINUE READING

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