Phospholipase C binds to the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae.

@article{Ansari1999PhospholipaseCB,
  title={Phospholipase C binds to the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae.},
  author={Kamran Ansari and Sally Martin and Mari{\'a}n Farka{\vs}ovsk{\'y} and I M Ehbrecht and Hans K{\"u}ntzel},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 42},
  pages={30052-8}
}
The hormone receptor-like protein Gpr1p physically interacts with phosphatidylinositol-specific phospholipase C (Plc1p) and with the Galpha protein Gpa2p, as shown by two-hybrid assays and co-immune precipitation of epitope-tagged proteins. Plc1p binds to Gpr1p in either the presence or absence of Gpa2, whereas the Gpr1p/Gpa2p association depends on the presence of Plc1p. Genetic interactions between the null mutations plc1Delta, gpr1Delta, gpa2Delta, and ras2Delta suggest that Plc1p acts… CONTINUE READING

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