Phospholipase C beta and membrane action of calcitriol and estradiol.

@article{Mellay1997PhospholipaseCB,
  title={Phospholipase C beta and membrane action of calcitriol and estradiol.},
  author={V{\'e}ronique Le Mellay and Brigitte Grosse and Mich{\`e}le Lieberherr},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 18},
  pages={
          11902-7
        }
}
We have shown that estrogens and calcitriol, the hormonally active form of vitamin D, increase the concentration of intracellular calcium ([Ca2+]i) within 5 s by mobilizing calcium from the endoplasmic reticulum and the formation of inositol 1,4, 5-trisphosphate and diacylglycerol. Because the activation of effectors as phospholipase C (PLC) coupled to G-proteins is the early event in the signal transduction pathway leading to the inositol 1,4,5-trisphosphate formation and to [Ca2+]i increase… CONTINUE READING

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