Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

@article{Dzhura2011PhospholipaseCL,
  title={Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.},
  author={Igor Dzhura and Oleg G. Chepurny and Colin A Leech and Michael W. Roe and Elvira V Dzhura and Xin Xu and Youming Lu and Frank Schwede and Hans-G Genieser and Alan V. Smrcka and George G. Holz},
  journal={Islets},
  year={2011},
  volume={3 3},
  pages={121-8}
}
Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is potentiated by cAMP-elevating agents, such as the incretin hormone glucagon-like peptide-1 (GLP-1), and cAMP exerts its insulin secretagogue action by activating both protein kinase A (PKA) and the cAMP-regulated guanine nucleotide exchange factor designated as Epac2. Although prior studies of mouse islets demonstrated that Epac2 acts via Rap1 GTPase to potentiate GSIS, it is not understood which downstream targets of Rap1… CONTINUE READING
22 Citations
61 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Epac 2 dependent mobilization of intracellular Ca 2 + by GLP - 1 receptor agonist Exendin - 4 is disrupted in beta cells of PLC - epsilon knockout mice

  • I Dzhura, OG Chepurny, GG Kelley, CA Leech, MW Roe, E Dzhura
  • J Physiol
  • 2010

Similar Papers

Loading similar papers…