Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domain

@article{Rossum2005PhospholipaseCC,
  title={Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domain},
  author={Damian B. van Rossum and Randen L. Patterson and Sumit Sharma and Roxanne K. Barrow and Michael Kornberg and Donald L Gill and Solomon H Snyder},
  journal={Nature},
  year={2005},
  volume={434},
  pages={99-104}
}
Many ion channels are regulated by lipids1,2,3, but prominent motifs for lipid binding have not been identified in most ion channels. Recently, we reported that phospholipase Cγ1 (PLC-γ1) binds to and regulates TRPC3 channels4, components of agonist-induced Ca2+ entry into cells. This interaction requires a domain in PLC-γ1 that includes a partial pleckstrin homology (PH) domain—a consensus lipid-binding and protein-binding sequence5,6. We have developed a gestalt algorithm to detect hitherto… CONTINUE READING
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