Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during wallerian degeneration

@article{De2003PhospholipaseAP,
  title={Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during wallerian degeneration},
  author={Susna De and Marcelino Avil{\'e}s Trigueros and Athena Kalyvas and SymonsJ. David},
  journal={Molecular and Cellular Neuroscience},
  year={2003},
  volume={24},
  pages={753-765}
}
Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid. The former can induce myelin breakdown and the latter, via eicosanoids, can stimulate inflammatory responses. Immunohistochemical analysis of secreted (sPLA(2)) and cytosolic (cPLA(2)) forms of the enzyme was assessed in the injured adult rat sciatic and optic nerves. sPLA(2) and cPLA(2) are expressed in the first 2 weeks in the injured sciatic nerve, which correlates with rapid Wallerian… CONTINUE READING
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