Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.

@article{Tithof1996PhospholipaseAI,
  title={Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.},
  author={Patricia K. Tithof and E Schiamberg and Marc Peters-Golden and Patricia E. Ganey},
  journal={Environmental Health Perspectives},
  year={1996},
  volume={104},
  pages={52 - 58}
}
Aroclor 1242, a mixture of polychlorinated biphenyls (PCBs), activates neutrophils to produce superoxide anion (O2-) by a mechanism that involves phospholipase C-dependent hydrolysis of membrane phosphoinositides; however, subsequent signal transduction mechanisms are unknown. We undertook this study to determine whether phospholipase A2-dependent release of arachidonic acid is involved in PCB-induced O2- production. We measured O2- production in vitro in glycogen-elicited, rat neutrophils in… CONTINUE READING