Phospholipase A2 inhibitors protect against prion and Aβ mediated synapse degeneration

@inproceedings{Bate2010PhospholipaseAI,
  title={Phospholipase A2 inhibitors protect against prion and Aβ mediated synapse degeneration},
  author={Clive Bate and Mourad Tayebi and Alun T Williams},
  booktitle={Molecular Neurodegeneration},
  year={2010}
}
An early event in the neuropathology of prion and Alzheimer's diseases is the loss of synapses and a corresponding reduction in the level of synaptophysin, a pre-synaptic membrane protein essential for neurotransmission. The molecular mechanisms involved in synapse degeneration in these diseases are poorly understood. In this study the process of synapse… CONTINUE READING