Phospholipase A2 hydrolysis of supported phospholipid bilayers: a neutron reflectivity and ellipsometry study.

@article{Vacklin2005PhospholipaseAH,
  title={Phospholipase A2 hydrolysis of supported phospholipid bilayers: a neutron reflectivity and ellipsometry study.},
  author={Hanna P Vacklin and Fredrik Tiberg and Giovanna Fragneto and Robert K Thomas},
  journal={Biochemistry},
  year={2005},
  volume={44 8},
  pages={2811-21}
}
We have investigated the phospholipase A(2) catalyzed hydrolysis of supported phospholipid bilayers using neutron reflection and ellipsometry. At the hydrophilic silica-water interface, hydrolysis of phosphatidylcholine bilayers by phospholipase A(2) from Naja mossambica mossambica venom is accompanied by destruction of the bilayer at an initial rate, which is comparable for DOPC and DPPC but is doubled for POPC. The extent of bilayer destruction at 25 degrees C decreases from DOPC to POPC and… CONTINUE READING

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