Phospholipase A2 expression in tumours: a target for therapeutic intervention?

@article{Laye2003PhospholipaseAE,
  title={Phospholipase A2 expression in tumours: a target for therapeutic intervention?},
  author={Jon Laye and J. Gill},
  journal={Drug discovery today},
  year={2003},
  volume={8 15},
  pages={
          710-6
        }
}
Phospholipase A(2) (PLA(2)) enzymes are involved in lipid metabolism and, as such, are central to several cellular processes. The different PLA(2)s identified to date can be classified into three groups: secreted PLA(2) (sPLA(2)), calcium-independent PLA(2) (iPLA(2)) and calcium-dependent cytosolic PLA(2) (cPLA(2)). In addition to their role in cellular signalling, PLA(2)s have been implicated in diverse pathological conditions, including inflammation, tissue repair and cancer. Elevated levels… Expand
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  • B. Cummings
  • Biology, Medicine
  • Biochemical pharmacology
  • 2007
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