Phospholipase A(2)-susceptible liposomes of anticancer double lipid-prodrugs.

  title={Phospholipase A(2)-susceptible liposomes of anticancer double lipid-prodrugs.},
  author={Ahmad Arouri and Ole G. Mouritsen},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={45 4},
A novel approach to anticancer drug delivery is presented based on lipid-like liposome-forming anticancer prodrugs that are susceptible to secretory phospholipase A(2) (sPLA(2)) that is overexpressed in several cancer types. The approach provides a selective unloading of anticancer drugs at the target tissues, as well as circumvents the necessity for "conventional" drug loading. In our attempts to improve the performance of the liposomes in vivo, several PEGylated and non-PEGylated liposomal… CONTINUE READING


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