Phospholipase A(2) is involved in thapsigargin-induced sodium influx in human lymphocytes.

@article{Nofer2000PhospholipaseAI,
  title={Phospholipase A(2) is involved in thapsigargin-induced sodium influx in human lymphocytes.},
  author={J R Nofer and Ralf Junker and Mark I. Walter and Udo Seedorf and G. A\ssmann and Walter Zidek and Martin Tepel},
  journal={Archives of biochemistry and biophysics},
  year={2000},
  volume={374 2},
  pages={
          213-21
        }
}

• J R Nofer, Ralf Junker, +4 authors Martin Tepel
• Published 2000 in Archives of biochemistry and biophysics

Previously, we reported that emptying of intracellular Ca(2+) pools with endoplasmatic Ca(2+)-ATP-ase inhibitor thapsigargin leads to the Na(+) influx in human lymphocytes (M. Tepel et al., 1994, J. Biol. Chem. 269, 26239-26242). In the present study we examined the mechanism underlying the thapsigargin-induced Na(+) entry. We found that the thapsigargin-induced increase in Na(+) concentration was effectively inhibited by three structurally unrelated phospholipase A(2) (PLA(2)) inhibitors, p… CONTINUE READING

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