Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes.

@article{Han2006PhospholemmanPM,
  title={Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes.},
  author={Fei Han and Julie Bossuyt and Sanda Despa and Amy L. Tucker and Donald M. Bers},
  journal={Circulation research},
  year={2006},
  volume={99 12},
  pages={
          1376-83
        }
}
Because phospholemman (PLM) regulates the Na(+)/K(+) pump (NKA) and is a major cardiac phosphorylation target for both protein kinase A (at Ser68) and protein kinase C (PKC) (at both Ser63 and Ser68), we evaluated whether PLM mediates the PKC-dependent regulation of NKA function and protein kinase A/PKC crosstalk in ventricular myocytes. PKC was activated by PDBu (300 nmol/L), and we measured NKA-mediated [Na(+)](i) decline (fluorescence measurements) and current (I(pump)) (voltage clamp). In… CONTINUE READING

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Phospholemmanphosphorylation mediates the PKC-dependent effects on Na /K pump function in cardiac myocytes

  • F Han, S Despa, J Bossuyt, L Jia, AL Tucker, DM. Bers
  • Biophys J. ;90:281A
  • 2006

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