Phospholamban forms Ca2+-selective channels in lipid bilayers.

  title={Phospholamban forms Ca2+-selective channels in lipid bilayers.},
  author={Richard J. Kovacs and Mark T. Nelson and Heather Simmerman and Larry R. Jones},
  journal={The Journal of biological chemistry},
  volume={263 34},
Phospholamban is the major membrane protein of the heart phosphorylated in response to beta-adrenergic stimulation. A role for phospholamban in the control of Ca2+ transport by the sarcoplasmic reticulum has been postulated, but the mechanism is incompletely understood. Structural characterization of the purified protein suggests that it is capable of forming a membrane-spanning pore (Simmerman, H. K. B., Collins, J. H., Theibert, J. L., Wegener, A. D., and Jones, L. R. (1986) J. Biol. Chem… CONTINUE READING


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