Phosphoinositides in cell regulation and membrane dynamics

  title={Phosphoinositides in cell regulation and membrane dynamics},
  author={Gilbert Di Paolo and Pietro De Camilli},
Inositol phospholipids have long been known to have an important regulatory role in cell physiology. The repertoire of cellular processes known to be directly or indirectly controlled by this class of lipids has now dramatically expanded. Through interactions mediated by their headgroups, which can be reversibly phosphorylated to generate seven species, phosphoinositides play a fundamental part in controlling membrane–cytosol interfaces. These lipids mediate acute responses, but also act as… 

Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes

  • Y. Orlov
  • Biology, Chemistry
    Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
  • 2015
The general features of the functioning of phosphoinositide system as an organizer and integrator of intracellular events are discussed.

Phosphoinositides in cell architecture.

This review examines the critical role phosphoinositides play in these processes to execute the establishment and maintenance of cellular architecture and how individual cells use phosphoinposide regulation to further organize into epithelial tissues.

Phosphoinositide‐metabolizing enzymes at the interface between membrane traffic and cell signalling

This work has provided important clues as to how regulated activation of PI‐metabolizing enzymes and recruitment of their binding proteins might cooperate in targeting distinct pools of PIs to different cell physiological functions.

Phosphoinositides in Control of Membrane Dynamics.

The functions of phosphoinositides in membrane dynamics during exocytosis, endocytoses, autophagy, cell division, cell migration, and epithelial cell polarity are discussed, with emphasis on protein effectors that are recruited by specific phosphoinposides during these processes.

Phosphoinositides and vesicular membrane traffic.

  • P. Mayinger
  • Biology, Chemistry
    Biochimica et biophysica acta
  • 2012

Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

Most enzymes involved in phosphoinositide synthesis are conserved between yeast and human, and their loss of function leads to severe diseases (cancer, myopathy, neuropathy and ciliopathy).

Phosphoinositides: Regulators of membrane traffic and protein function

SAC1 lipid phosphatase and growth control of the secretory pathway.

This review focuses on SAC1 lipid phosphatase and how this enzyme operates in an evolutionary conserved mechanism to coordinate the secretory capacity of ER and Golgi during cell growth.

Review of PIP2 in Cellular Signaling, Functions and Diseases

  • K. Mandal
  • Biology, Chemistry
    International journal of molecular sciences
  • 2020
This review summarizes recent findings that implicate dysregulation of PIP2 in many diseases and focuses on past and recent exciting results on different molecular mechanisms that regulate cellular functions by binding of specific proteins to PIP1 or by stabilizing phosphoinositide pools in different cellular compartments.



Nuclear phosphoinositides and their functions.

In this light, phosphoinositides and inositol polyphosphates might represent high turnover activity switches for nuclear complexes responsible for these processes, including DNA repair, transcription regulation and RNA dynamics.

Plasma membrane phosphoinositide organization by protein electrostatics

Recent studies suggest that membrane proteins concentrate PIP2 and, in response to local increases in intracellular calcium concentration, release it to interact with other biologically important molecules.

Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking.

  • T. Martin
  • Biology
    Annual review of cell and developmental biology
  • 1998
Common themes of localized signal generation and the spatially localized recruitment of effector proteins appear to underlie mechanisms employed in signal transduction, cytoskeletal, and membrane trafficking events.

Phosphoinositide regulation of the actin cytoskeleton.

This review presents tantalizing evidence that suggests how binding of selected cytoskeletal proteins to membrane PPIs may promote PPI clustering into raft lipid microdomains, alter their accessibility to other proteins, and even distort the bilayer conformation.

Phosphoinositides in constitutive membrane traffic.

  • M. Roth
  • Biology
    Physiological reviews
  • 2004
Although the lipid kinases and phosphatases that function in constitutive membrane traffic are beginning to be identified, their regulation is poorly understood.

Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.

  • M. WenkP. De Camilli
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
Powerful methods for the detection of lipids are rapidly advancing this field, thus complementing the broad range of information about biological systems that can be obtained from genomic and proteomic approaches.

The phosphoinositide 3-kinase pathway.

The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

Organelle identity and the signposts for membrane traffic

Recent studies have helped to establish how cells maintain and restrict these determinants and explain how this system is exploited by invading pathogens.

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

This review uses transgenic and knockout mouse studies where either PI3K or its signaling components are deregulated as a framework to build a profile of PI3k function within both the cell and the organism and focuses, in particular, on the role ofPI3K in cell regulation, immunity, and development.