Phosphoinositides: regulators of membrane traffic and protein function.

  title={Phosphoinositides: regulators of membrane traffic and protein function.},
  author={Michael Krauss and Volker Haucke},
  journal={FEBS letters},
  volume={581 11},
Phosphoinositides serve as important spatio-temporal regulators of intracellular trafficking and cell signalling events. In addition to their recognition by specific phosphoinositide binding domains present within cytoplasmic adaptor proteins or membrane integral channels and transporters phosphoinositides may affect membrane transport by eliciting conformational changes within proteins or by regulating enzymatic activities. During adaptor-mediated membrane traffic phosphoinositides form part… CONTINUE READING
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