Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors.

Abstract

Phosphoinositide signal transduction pathways in nuclei use enzymes that are indistinguishable from their cytosolic analogues. We demonstrate that distinct phosphatidylinositol phosphate kinases (PIPKs), the type I and type II isoforms, are concentrated in nuclei of mammalian cells. The cytosolic and nuclear PIPKs display comparable activities toward the… (More)

Topics

10 Figures and Tables

Cite this paper

@article{Boronenkov1998PhosphoinositideSP, title={Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors.}, author={Igor V. Boronenkov and Joost C Loijens and M. Umeda and R Andy Anderson}, journal={Molecular biology of the cell}, year={1998}, volume={9 12}, pages={3547-60} }