Phosphoinositide phosphatases in a network of signalling reactions

  title={Phosphoinositide phosphatases in a network of signalling reactions},
  author={Daniel Bl{\'e}ro and Bernard Payrastre and St{\'e}phane Schurmans and Christophe Erneux},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
Phosphoinositide phosphatases dephosphorylate the three positions (D-3, 4 and 5) of the inositol ring of the poly-phosphoinositides. They belong to different families of enzymes. The PtdIns(3,4)P2 4-phosphatase family, the tumour suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), SAC1 domain phosphatases and myotubularins belong to the tyrosine protein phosphatases superfamily. They share the presence of a conserved cysteine residue in the consensus CX5RT/S. Another… CONTINUE READING


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