Phosphoinositide phosphatases: just as important as the kinases.

@article{Dyson2012PhosphoinositidePJ,
  title={Phosphoinositide phosphatases: just as important as the kinases.},
  author={Jennifer M. Dyson and Clare G Fedele and Elizabeth Michele Davies and Jelena Becanovic and Christina A Mitchell},
  journal={Sub-cellular biochemistry},
  year={2012},
  volume={58},
  pages={215-79}
}
Phosphoinositide phosphatases comprise several large enzyme families with over 35 mammalian enzymes identified to date that degrade many phosphoinositide signals. Growth factor or insulin stimulation activates the phosphoinositide 3-kinase that phosphorylates phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)] to form phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P(3)], which is rapidly dephosphorylated either by PTEN (phosphatase and tensin homologue deleted on chromosome 10… CONTINUE READING
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