Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

@inproceedings{Poon2014PhosphoinositidemediatedOO,
  title={Phosphoinositide-mediated oligomerization of a defensin induces cell lysis},
  author={Ivan K H Poon and Amy A Baxter and Fung T Lay and Grant D. Mills and Christopher G. Adda and Jennifer A E Payne and Thanh Kha Phan and Gemma F. Ryan and Julie A. White and Prem K. Veneer and Nicole L. van der Weerden and Marilyn A. Anderson and Marc Kvansakul and Mark D Hulett},
  booktitle={eLife},
  year={2014}
}
Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells. Many CAPs act at the plasma membrane of cells leading to membrane destabilization and permeabilization. In this study, we describe a novel cell lysis mechanism for fungal and tumor cells by the plant defensin NaD1 that acts via direct binding to the plasma membrane phospholipid phosphatidylinositol 4,5… CONTINUE READING

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