Phosphoinositide isoforms determine compartment-specific ion channel activity.

  title={Phosphoinositide isoforms determine compartment-specific ion channel activity.},
  author={Xiaoli Zhang and Xinran Li and Haoxing Xu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 28},
Phosphoinositides serve as address labels for recruiting peripheral cytoplasmic proteins to specific subcellular compartments, and as endogenous factors for modulating the activity of integral membrane proteins. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is a plasma-membrane (PM)-specific phosphoinositide and a positive cofactor required for the activity of most PM channels and transporters. This requirement for phosphoinositide cofactors has been proposed to prevent PM channel… CONTINUE READING


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