Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance

@inproceedings{Tang2016PhosphoinositideIR,
  title={Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance},
  author={Min Tang and Guang-yi Wu and Xin-zhong Dong and Zongxiang Tang},
  booktitle={Acta Pharmacologica Sinica},
  year={2016}
}
Aim:Pirt is a two-transmembrane domain protein that regulates the function of a variety of ion channels. Our previous study indicated that Pirt acts as a positive endogenous regulator of the TRPM8 channel. The aim of this study was to investigate the mechanism underlying the regulation of TRPM8 channel by Pirt.Methods:HEK293 cells were transfected with… CONTINUE READING