Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4

@article{Nirula2006PhosphoinositidedependentK1,
  title={Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4},
  author={Ajay Nirula and Mary Wen-Reng Ho and Hyewon Phee and Jeroen Roose and Arthur Weiss},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={1733 - 1744}
}
CD28 plays a critical role in T cell immune responses. Although the kinase Akt has been shown to act downstream of CD28 in T helper (Th)1 cytokine induction, it does not induce Th2 cytokines such as interleukin 4 (IL-4). We recently reported that phosphoinositide-dependent kinase 1 (PDK1) partially corrects the defect in IL-4 production present in CD28-deficient T cells, suggesting that PDK1 regulates IL-4 independently of Akt. We now describe a signaling pathway in which PDK1 targets IL-4 in… CONTINUE READING

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