Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages.

@article{Chaurasia2010PhosphoinositidedependentK1,
  title={Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages.},
  author={Bhagirath Chaurasia and Jan Mauer and Linda Koch and Julia Goldau and Anja-Sterner Kock and Jens C. Br{\"u}ning},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 17},
  pages={4354-66}
}
Phosphoinositide-dependent kinase 1 (PDK-1) represents an important signaling component in the phosphatidylinositol 3-kinase (PI3K) pathway, which plays an essential role in controlling a coordinated innate immune response. Here, we show that mice with conditional disruption of PDK-1 specifically in myeloid lineage cells (PDK-1(Deltamyel) mice) show enhanced susceptibility to lipopolysaccharide (LPS)-induced septic shock accompanied by exaggerated liver failure. Furthermore, primary macrophages… CONTINUE READING