Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.

@article{Weber2004PhosphoinositidedependentK1,
  title={Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.},
  author={David Isaiah Sale Weber and Yoshihiro Taniyama and Petra Rocic and Puvi N Seshiah and Melissa A. Dechert and William T. Gerthoffer and Kathy K. Griendling},
  journal={Circulation research},
  year={2004},
  volume={94 9},
  pages={
          1219-26
        }
}
Smooth muscle cell migration in response to platelet-derived growth factor (PDGF) is a key event in several vascular pathologies, including atherosclerosis and restenosis. PDGF increases intracellular levels of reactive oxygen species (ROS) in vascular smooth muscle cells (VSMCs), but the ROS sensitivity of migration and of the signaling pathways leading to migration are largely unknown. In VSMCs, PDGF dose-dependently increased migration compared with nonstimulated cells, with a maximum… CONTINUE READING
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