Phosphoinositide Lipid Second Messengers: New Paradigms for Calcium Channel Modulation

  title={Phosphoinositide Lipid Second Messengers: New Paradigms for Calcium Channel Modulation},
  author={P. Delmas and B. Coste and N. Gamper and M. S. Shapiro},
  • P. Delmas, B. Coste, +1 author M. S. Shapiro
  • Published 2005
  • Medicine, Biology
  • Neuron
  • Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2… CONTINUE READING

    Figures and Topics from this paper.

    The lipid connection–regulation of voltage-gated Ca2+ channels by phosphoinositides
    • 52
    G Protein Regulation of Neuronal Calcium Channels: Back to the Future
    • 23
    • PDF
    Strategies for Investigating G-Protein Modulation of Voltage-Gated Ca2+ Channels.
    • 3
    Neuromodulation of Calcium Channels
    Phosphoinositide sensitivity of ion channels, a functional perspective.
    • 26
    The ß subunit of voltage-gated Ca2+ channels.
    • 264
    Regulation of Ca(V)2 calcium channels by G protein coupled receptors.
    • 103
    • Highly Influenced
    Pathways modulating neural KCNQ/M (Kv7) potassium channels
    • 528
    • PDF
    Regulation of ion transport proteins by membrane phosphoinositides
    • 196


    Publications referenced by this paper.
    Modulation of Ca2+ channels βγ G-protein py subunits
    • 682
    PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents
    • 449
    Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits
    • 794
    Functional organization of PLC signaling microdomains in neurons
    • 81
    • PDF
    Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2
    • 237
    • PDF
    Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate
    • 426
    Junctional Signaling Microdomains Bridging the Gap between the Neuronal Cell Surface and Ca2+ Stores
    • 74