Phosphoinositide 3-kinases as accelerators and brakes of autophagy.

  title={Phosphoinositide 3-kinases as accelerators and brakes of autophagy.},
  author={Fergal O Farrell and Tor Erik Rusten and Harald Stenmark},
  journal={The FEBS journal},
  volume={280 24},
Degradation of cytoplasmic material by autophagy plays a key role in protein homeostasis and metabolic control, as well as in the removal of intracellular protein aggregates, pathogens and damaged organelles. The concept of up- or down-regulating this pathway pharmacologically in neurodegenerative diseases, infections, inflammation and cancer is therefore attractive. Among the key pharmacological targets in regulation of autophagy are the phosphoinositide 3-kinases (PI3Ks), which mediate the… CONTINUE READING
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