Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.

@article{MedinaTato2007Phosphoinositide3S,
  title={Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.},
  author={David A Medina-Tato and Stephen Geoffrey Ward and Malcolm L. Watson},
  journal={Immunology},
  year={2007},
  volume={121 4},
  pages={448-61}
}
The family of lipid kinases termed phosphoinositide-3-kinase (PI3K) is known to contribute at multiple levels to innate and adaptive immune responses, and is hence an attractive target for drug discovery in inflammatory and autoimmune disease, including respiratory diseases. The development of isoform-selective pharmacological inhibitors, targeted gene manipulation and short interfering RNA (siRNA) target validation have facilitated a better understanding of the role that each member of this… CONTINUE READING

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