Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.

@article{Macrez2001Phosphoinositide3I,
  title={Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels.},
  author={Nathalie Macrez and Chantal Mironneau and Val{\'e}rie Carricaburu and Jean François Quignard and Aleksei Babich and Cornelia Czupalla and B. Meinecke N{\"u}rnberg and Jean Mironneau},
  journal={Circulation research},
  year={2001},
  volume={89 8},
  pages={692-9}
}
Heterodimeric class I phosphoinositide 3-kinase (PI3K) has been shown to be involved in the stimulation of voltage-gated Ca(2+) channels by various mediators. In this study, we bring evidences that vascular L-type Ca(2+) channels can be modulated by both tyrosine kinase-regulated class Ia and G protein-regulated class Ib PI3Ks. Purified recombinant PI3Ks increased the peak Ca(2+) channel current density when applied intracellularly. Furthermore, PI3Kalpha-, beta-, and delta-mediated… CONTINUE READING