Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells.

@article{Choi2010Phosphoinositide3I,
  title={Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells.},
  author={Keun Hwa Choi and Jong-Eun Kim and Nu Ry Song and Joe Eun Son and Mun Kyung Hwang and Sanguine Byun and Jong Hun Kim and Ki Won Lee and Hyong Joo Lee},
  journal={Cardiovascular research},
  year={2010},
  volume={85 4},
  pages={836-44}
}
AIMS Abnormal migration and proliferation of human aortic smooth muscle cells (HASMCs) to the intima causes intimal thickening of the aorta, which is strongly related to the development of atherosclerosis. Previous studies have suggested that red wine polyphenols, particularly resveratrol, have great protective effects against cardiovascular diseases. Here, we compared the anti-atherosclerotic effect of piceatannol, a metabolite of resveratrol, and its underlying mechanisms. METHODS AND… CONTINUE READING

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