Phosphoinositide 3-kinase gamma regulates airway smooth muscle contraction by modulating calcium oscillations.

@article{Jiang2010Phosphoinositide3G,
  title={Phosphoinositide 3-kinase gamma regulates airway smooth muscle contraction by modulating calcium oscillations.},
  author={Haihong Jiang and Peter W. Abel and Myron L. Toews and Caishu Deng and Thomas B. Casale and Yan Xie and Yaping Tu},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={334 3},
  pages={703-9}
}
Phosphoinositide 3-kinase gamma (PI3Kgamma) has been implicated in the pathogenesis of asthma, but its mechanism has been considered indirect, through release of inflammatory cell mediators. Because airway smooth muscle (ASM) contractile hyper-responsiveness plays a critical role in asthma, the aim of the present study was to determine whether PI3Kgamma can… CONTINUE READING