Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

@article{Oudit2003Phosphoinositide3G,
  title={Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.},
  author={Gavin Yadram Oudit and Michael A. Crackower and Urs Eriksson and Renu Sarao and Ivona Kozieradzki and Takehiko Sasaki and Junko Irie-Sasaki and Dominica Gidrewicz and Vitalyi O. Rybin and Teiji Wada and Susan F. Steinberg and Peter Backx and Josef M. Penninger},
  journal={Circulation},
  year={2003},
  volume={108 17},
  pages={2147-52}
}
BACKGROUND We have recently shown that genetic inactivation of phosphoinositide 3-kinase gamma (PI3Kgamma), the isoform linked to G-protein-coupled receptors, results in increased cardiac contractility with no effect on basal cell size. Signaling via the G-protein-coupled beta-adrenergic receptors has been implicated in cardiac hypertrophy and heart failure, suggesting that PI3Kgamma might play a role in the pathogenesis of heart disease. METHODS AND RESULTS To determine the role for… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…