Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

  title={Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.},
  author={Erica Martin and Danielle G Souza and Caio Tavares Fagundes and Flavio A Amaral and Barbara Assenzio and Valeria Puntorieri and Lorenzo Del Sorbo and Vito Fanelli and Martino Bosco and Luisa Delsedime and Jos{\'e} Felippe Pinho and Virg{\'i}nia Soares Lemos and Fabr{\'i}cio Oliveira Souto and Jos{\'e} Carlos F Alves-Filho and Fernando Q Cunha and Arthur S Slutsky and Thomas Ruckle and Emilio Hirsch and Mauro M Teixeira and V. Marco Ranieri},
  journal={American journal of respiratory and critical care medicine},
  volume={182 6},
RATIONALE Sepsis is a leading cause of death in the intensive care unit, characterized by a systemic inflammatory response (SIRS) and bacterial infection, which can often induce multiorgan damage and failure. Leukocyte recruitment, required to limit bacterial spread, depends on phosphoinositide-3 kinase γ (PI3Kγ) signaling in vitro; however, the role of this enzyme in polymicrobial sepsis has remained unclear. OBJECTIVES This study aimed to determine the specific role of the kinase activity… CONTINUE READING
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