Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.

@article{Martin2010Phosphoinositide3KG,
  title={Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.},
  author={Erica Martin and Danielle G Souza and Caio Tavares Fagundes and Flavio A Amaral and Barbara Assenzio and Valeria Puntorieri and Lorenzo Del Sorbo and Vito Fanelli and Martino Bosco and Luisa Delsedime and Jos{\'e} Felippe Pinho and Virg{\'i}nia Soares Lemos and Fabr{\'i}cio Oliveira Souto and Jos{\'e} Carlos F Alves-Filho and Fernando Q Cunha and Arthur S Slutsky and Thomas Ruckle and Emilio Hirsch and Mauro M Teixeira and V. Marco Ranieri},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={182 6},
  pages={762-73}
}
RATIONALE Sepsis is a leading cause of death in the intensive care unit, characterized by a systemic inflammatory response (SIRS) and bacterial infection, which can often induce multiorgan damage and failure. Leukocyte recruitment, required to limit bacterial spread, depends on phosphoinositide-3 kinase γ (PI3Kγ) signaling in vitro; however, the role of this enzyme in polymicrobial sepsis has remained unclear. OBJECTIVES This study aimed to determine the specific role of the kinase activity… CONTINUE READING
Highly Cited
This paper has 29 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2015

Similar Papers

Loading similar papers…