Phosphoinositide 3-kinase-dependent activation of Rac.

  title={Phosphoinositide 3-kinase-dependent activation of Rac.},
  author={Heidi C E Welch and W. John Coadwell and Len R. Stephens and Phillip T. Hawkins},
  journal={FEBS letters},
  volume={546 1},
The monomeric GTPase Rac and the lipid kinase phosphoinositide 3-kinase (PI3K) are intracellular signalling enzymes that each regulate a huge range of cellular functions. Their signalling pathways overlap. Several pathways lead from PI3K activation via the production of the lipid second messenger phosphatidylinositol (3,4,5)-triphosphate (PtdIns(3,4,5)P(3)) to the activation of guanine-nucleotide exchange factors (GEFs) that activate Rac. Vice versa, Rac can also stimulate the activation of… CONTINUE READING
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