Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes.

Abstract

Bruton's tyrosine kinase (Btk) acts downstream of phosphoinositide 3-kinase (PI3K) in a pathway required for B cell receptor (BCR)-dependent proliferation. We used DNA microarrays to determine what fraction of genes this pathway influences and to investigate whether PI3K and Btk mediate distinct gene regulation events. As complete loss-of-function mutations… (More)

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Cite this paper

@article{Fruman2002Phosphoinositide3A, title={Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes.}, author={David A Fruman and Gregory Z. Ferl and Sam S An and Amber C. Donahue and Anne B. Satterthwaite and Owen N Witte}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2002}, volume={99 1}, pages={359-64} }