Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy.

@article{Coffey2005Phosphoinositide3A,
  title={Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy.},
  author={John Calvin Coffey and Jian Wang and M Smith and Alan Laing and David Bouchier-Hayes and Tom G Cotter and Henry Paul Redmond},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 22},
  pages={20968-77}
}
Tumor removal remains the principal treatment modality in the management of solid tumors. The process of tumor removal may potentiate the resurgent growth of residual neoplastic tissue. Herein, we describe a novel murine model in which flank tumor cytoreduction is followed by accelerated local tumor recurrence. This model held for primary and recurrent tumors generated using a panel of human and murine (LS174T, DU145, SW480, SW640, and 3LL) cell lines and replicated accelerated tumor growth… CONTINUE READING
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