Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax

@article{Liu2001Phosphoinositide3KP,
  title={Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax},
  author={Yan Liu and Youxiang Wang and Munekazu Yamakuchi and Satoko Masuda and Takeshi Tokioka and Shoji Yamaoka and Ikuro Maruyama and Isao Kitajima},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={2514-2526}
}
Activated phosphoinositide 3-kinase (PI3K) and its downstream target Akt are essential for the fibroblast transformation induced by many viral products. Tax, encoded by human T-cell leukemia virus type I (HTLV-I), has been demonstrated to induce the transformation of rat fibroblast Rat-1 cell through NF-κB activation. By stable transfection of Rat-1 cells with expressing constructs of Tax and its mutant M47, which is defective in HTLV-I LTR transactivation, we selected their transformed clones… CONTINUE READING