Phosphoinositide-3-kinase/Akt survival signal pathways are implicated in neuronal survival after stroke

  title={Phosphoinositide-3-kinase/Akt survival signal pathways are implicated in neuronal survival after stroke},
  author={Heng Zhao and Robert Morris Sapolsky and G K Steinberg},
  journal={Molecular Neurobiology},
In recent years, the phosphoinositide-3-kinase/Akt cell survival signaling pathway has been increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by phosphorylation through the activation of receptor tyrosine kinases by growth factors. Although the upstream signaling components phosphoinositide-dependent protein kinase (PDK)1 and integrinlinked kinase enhance the activity of Akt, phsophatase and tensin homolog deleted on chromosome 10 (PTEN) decreases it… CONTINUE READING
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