Phosphoinositide 3-Kinase – Deficient Mice Are Protected From Isoproterenol-Induced Heart Failure

@inproceedings{Oudit2003Phosphoinositide3,
  title={Phosphoinositide 3-Kinase – Deficient Mice Are Protected From Isoproterenol-Induced Heart Failure},
  author={Gavin Yadram Oudit and Michael A. Crackower and Urs Eriksson and Renu Sarao and Ivona Kozieradzki and Takehiko Sasaki and Junko Irie-Sasaki and Dominica Gidrewicz and Vitalyi O. Rybin and Teiji Wada and Susan F. Steinberg and Peter Backx and Josef M. Penninger},
  year={2003}
}
Background—We have recently shown that genetic inactivation of phosphoinositide 3-kinase (PI3K ), the isoform linked to G-protein–coupled receptors, results in increased cardiac contractility with no effect on basal cell size. Signaling via the G-protein–coupled -adrenergic receptors has been implicated in cardiac hypertrophy and heart failure, suggesting that PI3K might play a role in the pathogenesis of heart disease. Methods and Results—To determine the role for PI3K in hypertrophy induced… CONTINUE READING

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