Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer.

  title={Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer.},
  author={Derek Zieker and Ingmar Koenigsrainer and Isabel Tritschler and Markus L{\"o}ffler and Stefan Beckert and Frank Traub and Kay Nieselt and Sarah B{\"u}hler and Michael Weller and Jochen Gaedcke and Russell S Taichman and Hinnak Northoff and Bj{\"o}rn L. D. M. Br{\"u}cher and Alfred Koenigsrainer},
  journal={International journal of cancer},
  volume={126 6},
Peritoneal carcinomatosis is a frequent finding in gastric cancer associated with a poor prognosis. The features that enable gastric tumors to disseminate are poorly understood until now. Previously, we showed elevated mRNA levels of phosphoglycerate kinase 1 (PGK1), an adenosine triphosphate-generating enzyme in the glycolytic pathway, the chemokine receptor 4 (CXCR4), the corresponding chemokine ligand 12 (CXCL12) and beta-catenin in specimens from gastric cancer patients with peritoneal… CONTINUE READING
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