Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice.

@article{Ilg2001PhosphoglycanRL,
  title={Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice.},
  author={Thomas Ilg and Magali Demar and Dorothee Harbecke},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 7},
  pages={4988-97}
}
The human pathogen Leishmania synthesizes phosphoglycans (PGs) formed by variably modified phosphodisaccharide [6-Galbeta1-4Manalpha1-PO(4)] repeats and mannooligosaccharide phosphate [(Manalpha1-2)(0-5)Manalpha1-PO(4)] caps that occur lipid-bound on lipophosphoglycan, protein-bound on proteophosphoglycans, and as an unlinked form. PG repeat synthesis has been described as essential for survival and development of Leishmania throughout their life cycle, including for virulence to the mammalian… CONTINUE READING

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