Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion*

@article{Stark2009PhosphoenolpyruvateCV,
  title={Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion*},
  author={R. Stark and Francisco Pasquel and A. Turcu and Rebecca L. Pongratz and M. Roden and G. Cline and G. Shulman and R. Kibbey},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={26578 - 26590}
}
  • R. Stark, Francisco Pasquel, +5 authors R. Kibbey
  • Published 2009
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • Pancreatic β-cells couple the oxidation of glucose to the secretion of insulin. Apart from the canonical KATP-dependent glucose-stimulated insulin secretion (GSIS), there are important KATP-independent mechanisms involving both anaplerosis and mitochondrial GTP (mtGTP). How mtGTP that is trapped within the mitochondrial matrix regulates the cytosolic calcium increases that drive GSIS remains a mystery. Here we have investigated whether the mitochondrial isoform of phosphoenolpyruvate… CONTINUE READING
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