Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion*

@inproceedings{Stark2009PhosphoenolpyruvateCV,
  title={Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion*},
  author={Romana Stark and Francisco Pasquel and Adina F Turcu and Rebecca L. Pongratz and Michael Roden and Gary W. Cline and Gerald I Shulman and Richard Glenn Kibbey},
  booktitle={The Journal of biological chemistry},
  year={2009}
}
Pancreatic beta-cells couple the oxidation of glucose to the secretion of insulin. Apart from the canonical K(ATP)-dependent glucose-stimulated insulin secretion (GSIS), there are important K(ATP)-independent mechanisms involving both anaplerosis and mitochondrial GTP (mtGTP). How mtGTP that is trapped within the mitochondrial matrix regulates the cytosolic calcium increases that drive GSIS remains a mystery. Here we have investigated whether the mitochondrial isoform of phosphoenolpyruvate… CONTINUE READING