Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.

@article{Stangherlin2012PhosphodiesterasesAS,
  title={Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.},
  author={Alessandra Stangherlin and Manuela Zaccolo},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={302 2},
  pages={H379-90}
}
Phosphodiesterases are key enzymes in the cAMP signaling cascade. They convert cAMP in its inactive form 5'-AMP and critically regulate the intensity and the duration of cAMP-mediated signals. Multiple isoforms exist that possess different intracellular distributions, different affinities for cAMP, and different catalytic and regulatory properties. This complex repertoire of enzymes provides a multiplicity of ways to modulate cAMP levels, to integrate more signaling pathways, and to respond to… CONTINUE READING

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