Phosphodiesterases and regulation of female reproductive function.

  title={Phosphodiesterases and regulation of female reproductive function.},
  author={M. P{\'e}rez-D{\'i}az Conti},
  journal={Current opinion in pharmacology},
  volume={11 6},
The function of the mammalian follicle is regulated by circulating gonadotropins and a myriad of local paracrine regulations functioning within the ovary. Cyclic nucleotide signaling plays an essential role in mediating both these endocrine and paracrine regulations. Given their role in controlling cyclic nucleotide levels, cyclic nucleotide phosphodiesterases (PDEs) are critical for ovarian function. PDEs modulate gonadotropin responses in the somatic compartment of the ovarian follicle… CONTINUE READING