Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.

@article{Santing1995PhosphodiesteraseIR,
  title={Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.},
  author={R. E. Santing and C. G. Olymulder and K Van der Molen and Hermanus Meurs and Johan Zaagsma},
  journal={European journal of pharmacology},
  year={1995},
  volume={275 1},
  pages={
          75-82
        }
}
A new guinea pig model of allergic asthma was used to investigate the effects of low doses of the phosphodiesterase inhibitors, rolipram (phosphodiesterase IV selective), ORG 20241 (N-hydroxy-4-(3,4-dimethoxyphenyl)-thiazole-2-carboximidamide; dual phosphodiesterase III/IV inhibitor with some selectivity for the phosphodiesterase IV isoenzyme), and of theophylline (non-selective) on allergen-induced early and late phase asthmatic reactions, bronchial hyperreactivity to histamine inhalation, and… CONTINUE READING

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