Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats.

@article{Devan2004PhosphodiesteraseIB,
  title={Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats.},
  author={Bryan D. Devan and Demetrio Sierra-Mercado and M. T. De Anta Jimenez and Jonna L. Bowker and Kara B. Duffy and Edward L. Spangler and Donald K. Ingram},
  journal={Pharmacology, biochemistry, and behavior},
  year={2004},
  volume={79 4},
  pages={691-9}
}
We examined whether treatment with sildenafil citrate (the active compound of Viagra), a cyclic nucleotide phosphodiesterase type 5 inhibitor (PDE5), would reverse the learning impairment induced by cholinergic muscarinic (mACh) receptor blockade [0.75 mg/kg scopolamine HCl, intraperitoneal (i.p.) injections]. Rats were pretrained in a one-way active avoidance of foot shock in a straight runway and the next day received 15 training trials in a 14-unit T-maze. Performance in this maze paradigm… CONTINUE READING