Phosphodiesterase activity is regulated by CC2D1A that is implicated in non-syndromic intellectual disability

@inproceedings{AlTawashi2013PhosphodiesteraseAI,
  title={Phosphodiesterase activity is regulated by CC2D1A that is implicated in non-syndromic intellectual disability},
  author={Azza R Al-Tawashi and Chris Gehring},
  booktitle={Cell Communication and Signaling},
  year={2013}
}
Cyclic adenosine 3′,5′-monophosphate (cAMP) is a key regulator of many cellular processes, including in the neuronal system, and its activity is tuned by Phosphodiesterase (PDE) activation. Further, the CC2D1A protein, consisting of N-Terminal containing four DM14 domains and C-terminal containing C2 domain, was shown to regulate the cAMP-PKA pathway. A human deletion mutation lacking the fourth DM14 and the adjacent C2 domain results in Non Syndromic Intellectual Disability (NSID) also… CONTINUE READING
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