Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models

@inproceedings{Hu2010PhosphodiesteraseT5,
  title={Phosphodiesterase Type 5 Inhibitors Increase Herceptin Transport and Treatment Efficacy in Mouse Metastatic Brain Tumor Models},
  author={Jinwei Hu and Julia Y. Ljubimova and Satoshi Inoue and Bindu Konda and Rameshwar Patil and Hui Ding and Andres Espinoza and Kolja A. Wawrowsky and Chirag L Patil and Alexander V Ljubimov and Keith L. Black},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However, drug delivery into primary brain tumors and metastases is impeded by the blood-brain tumor barrier (BTB), significantly limiting drug use in brain cancer treatment. METHODOLOGY/PRINCIPAL FINDINGS We examined the effect of phosphodiesterase 5 (PDE5) inhibitors in nude mice on drug delivery to intracranially implanted human lung and breast… CONTINUE READING
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