Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer ’ s Disease

@inproceedings{Bales2011PhosphodiesteraseIT,
  title={Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer ’ s Disease},
  author={Kelly R. Bales and Niels Plath and Niels Svenstrup and Frank S. Menniti},
  year={2011}
}
Alzheimer’s Disease (AD) is a disease of synaptic dysfunction that ultimately proceeds to neuronal death. There is a wealth of evidence that indicates the final common mediator of this neurotoxic process is the formation and actions on synaptotoxic b-amyloid (Ab). The premise in this review is that synaptic dysfunction may also be an initiating factor in for AD and promote synaptotoxic Ab formation. This latter hypothesis is consistent with the fact that the most common risk factors for AD… CONTINUE READING